The interplay between dietary factors, gut microbiome and colorectal cancer: a new era of colorectal cancer prevention

Author:

Seesaha Poshita Kumari1ORCID,Chen Xiaofeng1,Wu Xiaofeng2,Xu Hongxia3,Li Changxian2,Jheengut Yogesh1,Zhao Fengjiao1,Liu Li4,Zhang Diancai5

Affiliation:

1. Oncology Department, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, PR China

2. Hepatobiliary Center, The First Affiliated Hospital, Nanjing Medical University, Jiangsu, PR China

3. Department of Nutrition, Third Military Medical University Daping Hospital & Research Institute of Surgery, Chongqing 400042, Sichuan, PR China

4. School of Public Health, Guizhou Medical University, Guiyang, PR China

5. Department of General Surgery, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, PR China

Abstract

Colorectal cancer is the third most common cancer in the world and its incidence is on the rise. Dietary intervention has emerged as an attractive strategy to curtail its occurrence and progression. Diet is known to influence the gut microbiome, as dietary factors and gut bacteria can act in concert to cause or protect from colorectal cancer. Several studies have presented evidence for such interactions and have pointed out the different ways by which the diet and gut microbiome can be altered to produce beneficial effects. This review article aims to summarize the interrelationship between diet, gut flora and colorectal cancer so that a better preventive approach can be applied.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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