Preoperative platelet–lymphocyte ratio predicts recurrence of laryngeal squamous cell carcinoma

Abstract

Aim: To evaluate the impact of preoperative platelet–lymphocyte ratio (PLR), neutrophil–lymphocyte ratio (NLR), derived NLR (dNLR) and lymphocyte–monocyte ratio (LMR) on the prognosis of laryngeal squamous cell carcinoma. Materials & methods: Overall survival and recurrence-free survival (RFS) were analyzed using Kaplan–Meier estimates. Multivariable Cox regression model was used to evaluate the independent prognostic significance of variables. Results: High PLR (>103.96), NLR (>1.96) and dNLR (>1.70) predicted lower RFS according to Kaplan–Meier method. In COX regression model, patients with high PLR had poor RFS estimates compared with those with lower PLR (p < 0.001). Conclusion: Preoperative PLR was a more valuable prognostic factor than NLR, dNLR and LMR for the recurrence of laryngeal squamous cell carcinoma.