Low expression of <i>GOT2</i> promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma-Reference-Cited by-全球学者库

Low expression of GOT2 promotes tumor progress and predicts poor prognosis in hepatocellular carcinoma

Published:2023-09 Issue:18 Volume:17 Page:755-765
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Liang Qiuli¹²^ORCID,Liu Shun¹,Yin Fuqiang³⁴,Liu Meiliang¹,Wang Lijun¹,Guo Erna¹⁵,Lei Lei¹,Wu Liuyu⁶,Yang Yu¹,Zhang Di⁷,Zeng Xiaoyun¹⁴

Affiliation:

1. School of Public Health, Guangxi Medical University, Nanning, Guangxi, 530021, China

2. Nanning Center for Disease Control & Prevention, Nanning, Guangxi, 530002, China

3. Life Sciences Institute Guangxi Medical University, Nanning, Guangxi, 530021, China

4. Key Laboratory of High-Incidence-Tumor Prevention & Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, 530021, China

5. School of International Education, Guangxi Medical University, Nanning, Guangxi, 530021, China

6. Department of Hospital Infection Control, Liuzhou People’s Hospital, Liuzhou, Guangxi, 545026, China

7. Department of Scientific Research, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China

Abstract

Background: To explore the biological function and the underlying mechanisms of GOT2 in hepatocellular carcinoma (HCC). Materials & methods: The expression level and prognostic value of GOT2 were examined using International Cancer Genome Consortium and International Cancer Proteogenome Consortium databases. The cell counting kit-8 method, clone formation, Transwell® assays and western blotting were used to evaluate the effects of GOT2 on the biological function and autophagy of HCC cells. Results: The expression of GOT2 was downregulated in HCC tissues and correlated with poor prognosis of HCC patients. Knockdown of GOT2 promoted proliferation, migration and invasion of HCC cells and promoted cells’ proliferation by inducing autophagy. Conclusion: GOT2 plays a tumor-inhibitory role in HCC and may be a potential therapeutic target for HCC.

Funder

the Natural Science Foundation of Guangxi

Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2023-0236

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