Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma

Author:

Wang Zuo1,Yuan Hang2,Zhu Xiong3,Wang Jinxia4,Xiu Wenbo4,Chen Yang4,Zhang Gao4,Fu Jing4,Peng Kun4,Li An4,Liu Donghua4,Huang Xijing4,He Chong45ORCID,Lu Fang456ORCID

Affiliation:

1. Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China

2. Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China

3. Department of Prenatal Diagnosis, Chengdu Women’s & Children’s Central Hospital, School of Medicine, University of Electronic Science & Technology of China, Chengdu, China

4. Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

5. Medico-Engineering Cooperation on Applied Medicine Research Center, University of Electronic Science & Technology of China, Chengdu, China

6. Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

Abstract

Objective: The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. Methods: A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay. Results: The median fecal calprotectin levels were significantly elevated in glaucoma (73.67 vs 41.97 μg/g; p < 0.001), primary angle-closure glaucoma (76.85 μg/g; p < 0.001) and primary open-angle glaucoma (69.29 μg/g; p = 0.016) groups compared with controls. A notable proportion of the glaucoma (24%; p < 0.001), primary angle-closure glaucoma (21%; p < 0.001) and primary open-angle glaucoma (24%; p < 0.001) subgroups exhibited highly abnormal fecal calprotectin levels (≥250 μg/g). Conclusion: Elevated fecal calprotectin might indicate potential intestinal inflammation in glaucoma.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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