Serum homocysteine relates to elevated lipid level, inflammation and major adverse cardiac event risk in acute myocardial infarction patients

Abstract

Aim: This study aimed to evaluate association of homocysteine (Hcy) with major adverse cardiac event (MACE) risk in acute myocardial infarction (AMI). Methods: Serum Hcy data from 196 AMI and 20 angina pectoris patients were retrieved from a hospital's electronic system. AMI patients attended a median of 21.2-month follow-up. Results: Hcy was elevated in AMI patients compared with angina pectoris patients (p = 0.020). In AMI patients, Hcy was positively related to total cholesterol, low-density lipoprotein cholesterol, C-reactive protein, infarct size, TNF-α and IL-6, while inversely linked with IL-10 (all p < 0.05). Hcy was independently associated with high MACE risk in AMI patients (p = 0.024). Conclusion: Serum Hcy correlates with elevated lipid levels, inflammation, infarct size and MACE risk in AMI patients.