Sex- and tissue-specific effects of binge-level prenatal alcohol consumption on DNA methylation at birth-Reference-Cited by-同舟云学术

Sex- and tissue-specific effects of binge-level prenatal alcohol consumption on DNA methylation at birth

Published:2021-12 Issue:24 Volume:13 Page:1921-1938
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Loke Yuk Jing¹²^ORCID,Muggli Evelyne²³⁴^ORCID,Saffery Richard¹²^ORCID,Ryan Joanne¹⁵^ORCID,Lewis Sharon²⁴^ORCID,Elliott Elizabeth J⁶⁷^ORCID,Halliday Jane²⁴^ORCID,Craig Jeffrey M¹²⁸^ORCID

Affiliation:

1. Molecular Immunity, Murdoch Children's Research Institute, Victoria, 3052, Australia

2. Department of Paediatrics, University of Melbourne, Victoria, 3010, Australia

3. Victorian Infant Brain Studies, Murdoch Children's Research Institute, Victoria, 3052, Australia

4. Reproductive Epidemiology, Murdoch Children's Research Institute, Victoria, 3052, Australia

5. Biological Neuropsychiatry & Dementia Unit, School of Public Health, Monash University, Victoria, 3004, Australia

6. Specialty of Child & Adolescent Health, Faculty of Medicine & Health, University of Sydney, NSW, 2050, Australia

7. The Australian Paediatric Surveillance Unit, Sydney Children's Hospital Network, NSW, 2045, Australia

8. The Institute of Mental & Physical Health & Clinical Translation, Deakin University, Victoria, 3220, Australia

Abstract

Background: Binge-level prenatal alcohol exposure (PAE) causes developmental abnormalities, which may be mediated in part by epigenetic mechanisms. Despite this, few studies have characterised the association of binge PAE with DNA methylation in offspring. Methods: We investigated the association between binge PAE and genome-wide DNA methylation profiles in a sex-specific manner in neonatal buccal and placental samples. Results: We identified no differentially methylated CpGs or differentially methylated regions (DMRs) at false discovery rate <0.05. However, using a sum-of-ranks approach, we identified a DMR in each tissue of female offspring. The DMR identified in buccal samples is located near regions with previously-reported associations to fetal alcohol spectrum disorder (FASD) and binge PAE. Conclusion: Our findings warrant further replication and highlight a potential epigenetic link between binge PAE and FASD.

Funder

Medical Research Future Fund Next Generation Fellowship

National Health and Medical Research Council

McCusker Charitable Trust

Victorian State Government's Operational Infrastructure Support Program

Financial Markets Foundation for Children

Jack Brockhoff Foundation

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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