Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis-Reference-Cited by-同舟云学术

Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis

Published:2022-01 Issue:1 Volume:14 Page:11-25
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Musanabaganwa Clarisse¹²³⁴^ORCID,Wani Agaz H³^ORCID,Donglasan Janelle³^ORCID,Fatumo Segun⁵⁶^ORCID,Jansen Stefan⁷^ORCID,Mutabaruka Jean²^ORCID,Rutembesa Eugene²^ORCID,Uwineza Annette¹^ORCID,Hermans Erno J⁴^ORCID,Roozendaal Benno⁴^ORCID,Wildman Derek E³^ORCID,Mutesa Leon¹^ORCID,Uddin Monica³^ORCID

Affiliation:

1. Centre for Human Genetics, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda

2. Department of Clinical Psychology, College of Medicine & Health Sciences, University of Rwanda, Huye, Rwanda

3. Genomics Program, College of Public Health, University of South Florida, Tampa, FL, USA

4. Department of Cognitive Neuroscience, Radboud University Medical Center – Donders Institute for Brain, Cognition & Behaviour, Radboud University, Nijmegen, The Netherlands

5. London School of Hygiene & Tropical Medicine, London, UK

6. Uganda Medical Informatics Centre-MRC/UVRI, Entebbe, Uganda

7. Directorate of Research & Innovation, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda

Abstract

Aim & methods: We conducted a pilot epigenome-wide association study of women from Tutsi ethnicity exposed to the genocide while pregnant and their resulting offspring, and a comparison group of women who were pregnant at the time of the genocide but living outside of Rwanda.Results: Fifty-nine leukocyte-derived DNA samples survived quality control: 33 mothers (20 exposed, 13 unexposed) and 26 offspring (16 exposed, 10 unexposed). Twenty-four significant differentially methylated regions (DMRs) were identified in mothers and 16 in children. Conclusions: In utero genocide exposure was associated with CpGs in three of the 24 DMRs: BCOR, PRDM8 and VWDE, with higher DNA methylation in exposed versus unexposed offspring. Of note, BCOR and VWDE show significant correlation between brain and blood DNA methylation within individuals, suggesting these peripherally derived signals of genocide exposure may have relevance to the brain.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Reference71 articles.

1. Pathways from assaultive violence to post-traumatic stress, depression, and generalized anxiety symptoms through stressful life events: longitudinal mediation models

2. A prospective study of posttraumatic stress disorder symptoms and coronary heart disease in women.

3. Prospective Study of Posttraumatic Stress Disorder Symptoms and Coronary Heart Disease in the Normative Aging Study

4. POTENTIALLY TRAUMATIC EVENTS AND THE RISK OF SIX PHYSICAL HEALTH CONDITIONS IN A POPULATION-BASED SAMPLE

5. The association between number and type of traumatic life experiences and physical conditions in a nationally representative sample

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