Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

Author:

Mamo Tewodros12,Moseman E Ashley3,Kolishetti Nagesh14,Salvador-Morales Carolina14,Shi Jinjun14,Kuritzkes Daniel R5,Langer Robert46,Andrian Ulrich von3,Farokhzad Omid C14

Affiliation:

1. Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA.

2. Nanotechnology Engineering, University of Waterloo, Canada

3. Department of Pathology, Harvard Medical School, USA

4. Harvard-MIT Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, MA, USA

5. Section for Retroviral Therapeutics, Brigham and Women’s Hospital, Harvard Medical School, USA

6. Department of Chemical Engineering, Massachusetts Institute of Technology, USA

Abstract

Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century. It has a vast potential to radically advance the treatment and prevention of HIV/AIDS. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for HIV/AIDS by advancing antiretroviral therapy, gene therapy, immunotherapy, vaccinology and microbicides.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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