<i>MIR27A</i> rs895819 TC Genotype Increases Risk of Fluoropyrimidine-Induced Severe Toxicity Independently of <i>DPYD</i> Variations-Reference-Cited by-同舟云学术

MIR27A rs895819 TC Genotype Increases Risk of Fluoropyrimidine-Induced Severe Toxicity Independently of DPYD Variations

Published:2024-01 Issue:2 Volume:25 Page:59-67
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Ragia Georgia¹²^ORCID,Biziota Eirini³,Koukaki Triantafyllia³,Amarantidis Kyriakos³,Manolopoulos Vangelis G¹²⁴^ORCID

Affiliation:

1. Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, 68100, Greece

2. Individualised Medicine & Pharmacological Research Solutions Center (IMPReS), Alexandroupolis, Greece

3. Department of Medical Oncology, University General Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, 68100, Greece

4. Clinical Pharmacology Unit, Academic General Hospital of Alexandroupolis, Alexandroupolis, Greece

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.2217/pgs-2023-0223

Reference24 articles.

1. Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

2. EMA . EMA recommendations on DPD testing prior to treatment with fluorouracil capecitabine tegafur and flucytosine. (2020). www.ema.europa.eu/en/news/ema-recommendations-dpd-testing-prior-treatment-fluorouracil-capecitabine-tegafur-and-flucytosine

3. Dihydropyrimidine Dehydrogenase Deficiency and Implementation of Upfront DPYD Genotyping

4. Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk

5. microRNAs miR-27a and miR-27b Directly Regulate Liver Dihydropyrimidine Dehydrogenase Expression through Two Conserved Binding Sites

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1. MIR27A Gene Polymorphism Modifies the Effect of Common DPYD Gene Variants on Severe Toxicity in Patients with Gastrointestinal Tumors Treated with Fluoropyrimidine-Based Anticancer Therapy;International Journal of Molecular Sciences;2024-08-04