Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients-Reference-Cited by-同舟云学术

Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients

Published:2008-11 Issue:11 Volume:9 Page:1595-1603
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Dmitrzak-Weglarz Monika¹,Rybakowski Janusz K²,Suwalska Aleksandra²,Skibinska Maria¹,Leszczynska-Rodziewicz Anna¹,Szczepankiewicz Aleksandra¹,Hauser Joanna¹

Affiliation:

1. Laboratory of Psychiatric Genetics, Department of Psychiatry, University of Medical Sciences, Poznan, Poland, ul. Szpitalna 27/33, 60-572 Poznan, Poland.

2. Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland

Abstract

The neuroplasticity hypothesis of bipolar disorder indicates that the BDNF/Trk signaling pathway is associated with the pathogenesis of this illness and treatment with mood stabilizers, such as lithium. This paper describes a relationship between response to lithium prophylaxis and polymorphisms of two functionally connected genes: BDNF and NTRK2, in bipolar illness. Analyses of four SNPs of the BDNF gene (rs2030324, rs988748, rs6265 [Val66Met]and rs2203877) and three of the NTRK2 gene (rs1187326, rs2289656, rs1187327) were performed in the 108 bipolar patients, classified as excellent responders (23%), partial responders (51%) and nonresponders (26%) to lithium. An association of C/G (rs988748) and G/A (rs6265) polymorphisms of the BDNF gene with a degree of prophylactic lithium response were found. No association with lithium response was revealed with the polymorphism of NTRK2 gene, neither with interaction of BDNF and NTRK2 genes.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/14622416.9.11.1595

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