Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis-Reference-Cited by-同舟云学术

Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis

Published:2015-09 Issue:9 Volume:10 Page:1433-1445
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Chen Zhao-Fei¹,Ai Luo-Yan¹,Wang Ji-Lin¹,Ren Lin-Lin¹,Yu Ya-Nan¹,Xu Jie¹,Chen Hao-Yan¹,Yu Jun²,Li Min³,Qin Wen-Xin⁴,Ma Xiong¹,Shen Nan⁵,Chen Ying-Xuan¹,Hong Jie¹,Fang Jing-Yuan¹

Affiliation:

1. Division of Gastroenterology & Hepatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China

2. Department of Medicine & Therapeutics, Institute of Digestive Disease & LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

3. Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China

4. State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University Shanghai, China

5. Division of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China

Abstract

Aims: To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. Materials & methods: The effects of C. butyricum and B. subtilis on CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced CRC were intervened by these two probiotics and the antitumor effects were examined by comparing the tumor incidence and detecting the inflammatory and immune-related markers. Results & conclusions: C. butyricum and B. subtilis inhibited the proliferation of CRC cells, caused cell cycle arrest and promoted apoptosis. In vivo, these two probiotics inhibited the development of DMH-induced CRC. The molecular mechanism involved reduced inflammation and improved immune homeostasis. This work establishes a basis for the protective role of probiotics B. subtilis and C. butyricum in intestinal tumorigenesis.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb.15.66

Reference40 articles.

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