HLA-DQB1*03 and DRB1*07 alleles increase the risk of cervical cancer among Uighur and Han women in Xinjiang, China-Reference-Cited by-同舟云学术

HLA-DQB1*03 and DRB1*07 alleles increase the risk of cervical cancer among Uighur and Han women in Xinjiang, China

Published:2018-08 Issue:20 Volume:14 Page:2005-2011
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Hu Jian Ming¹²,Liang Wei Hua¹,Qi Cui Hua³,Wang Xue Li¹²,Pan Xiao Lin¹,Qi Li Wen⁴,Shen Xi Hua²,Li Jiang Fen¹²,Xie Yu Fang¹²,Pang Li Juan¹,Liu Chun Xia¹,Zhang Hai Jun²,Tao Lin¹,Li Feng¹⁵

Affiliation:

1. Department of Pathology & Key Laboratory of Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, 832003, PR China

2. Department of Pathology, First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, 832003, PR China

3. Department of Digestion, First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, 832003, PR China

4. Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637100, PR China

5. Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, PR China

Abstract

Aim: To explore the association between the determinant factors including HLA-DQB1*03, DRB1-*07, -*13 and high-risk HPV infection, the cervical squamous cell carcinoma (CSCC) pathogenesis among Chinese Uighur and Han population. Materials & methods: HLA alleles were genotyped by PCR sequence-specific primers. Results: HPV16 infection rate was significantly higher among the Uighurs and Hans with CSCC as compared with healthy controls, respectively. HLA-DQB1*03 significantly increased among Uighurs with CSCC, while HLA-DRB1*07 significantly increased among Hans with CSCC. Similar tendencies were observed for DQB1*03 with HPV16-positive Uighurs CSCC and DRB1*07 with HPV16-positive Hans CSCC. Conclusion: This study suggests that HLA-DQB1*03 and DRB1*07 alleles may influence the immune response to HPV16 infection and increase the risk of CSCC among the Uighurs and Hans in China.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2018-0048

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