<i>In vitro</i> elimination of EL4 cancer cells from spermatogonia stem cells by miRNA-143- and 206-loaded folic acid-conjugated PLGA nanoparticles-Reference-Cited by-同舟云学术

In vitro elimination of EL4 cancer cells from spermatogonia stem cells by miRNA-143- and 206-loaded folic acid-conjugated PLGA nanoparticles

Published:2022-04 Issue:8 Volume:17 Page:531-545
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Shams Azar¹²,Shabani Ronak¹²,Asgari Hamidreza²^ORCID,Karimi Mahdi³^ORCID,Najafi Mohammad⁴^ORCID,Asghari-Jafarabadi Mohammad⁵⁶^ORCID,Razavi Seyed Mohsen⁷^ORCID,Miri Seyed Rouhollah⁸^ORCID,Abbasi Mehdi⁹^ORCID,Mohammadi Amirhossein²,Koruji Morteza¹²^ORCID

Affiliation:

1. Stem Cell & Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran

2. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

3. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

4. Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

5. Department of Statistics & Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

6. Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

7. Clinic of Hematology & Oncology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

8. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Science, Tehran, Iran

9. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Aim: MiRNA's-143 and -206 are powerful apoptotic regulators in cancer cells. This study aimed to use miRNA-143- and 206-loaded poly(lactic- co-glycolic) acid (PLGA) nanoparticles conjugated with folic acid to induce apoptosis in the EL4 cancer cells. Materials & methods: The therapy was conducted in six groups: treatment with both miRNAs simultaneously (mixed miRNAs), miRNA-206 treatment, miRNA-143 treatment, blank PLGA, blank polyethylenimine (PEI) and complex PEI-miRNAs. Results: In terms of viability, in mixed miRNAs no synergistic effect was observed on EL4 cell elimination. However, in the single miRNA-206 group, a stronger apoptotic effect was observed than the mixed miRNAs group and single miRNA-143 group alone. Conclusion: MiRNAs' apoptotic induction effects in cancer cells were found to be remarkable.

Funder

Iran University of Medical Sciences

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2021-0210

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