Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats-Reference-Cited by-同舟云学术

Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats

Published:2024-02-02 Issue: Volume: Page:
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Yuan Mengshu¹,Wang Yuxin¹,Tian Xiaorong¹,Zheng Weiping²³,Zuo Huaiwen¹,Zhang Xinru¹,Song Hongli²⁴

Affiliation:

1. Tianjin First Central Hospital Clinic Institute, Tianjin Medical University, Tianjin, 300070, PR China

2. Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin, 300192, PR China

3. NHC Key Laboratory of Critical Care Medicine, Tianjin, 300192, PR China

4. Tianjin Key Laboratory of Organ Transplantation, Tianjin, PR China

Abstract

Aims: To investigate the effects of Ferrostatin-1 (Fer-1) on improving the prognosis of liver transplant recipients with steatotic liver grafts and regulating gut microbiota in rats. Methods: We obtained steatotic liver grafts and established a liver transplantation model. Recipients were divided into sham, liver transplantation and Fer-1 treatment groups, which were assessed 1 and 7 days after surgery (n = 6). Results & conclusion: Fer-1 promotes recovery of the histological structure and function of steatotic liver grafts and the intestinal tract, and improves inflammatory responses of recipients following liver transplantation. Fer-1 reduces gut microbiota pathogenicity, and lowers iron absorption and improves fat metabolism of recipients, thereby protecting steatotic liver grafts.

Funder

National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2023-0133

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