Butyrate affects bacterial virulence: a new perspective on preventing enteric bacterial pathogen invasion

Author:

Liu Xiucheng12ORCID,Tang Hao2,Huang Xinxiang2,Xu Min13

Affiliation:

1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212008, China

2. Department of Biochemistry & Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, Jiangsu, 212013, China

3. Institute of Digestive Diseases, Jiangsu University, Zhenjiang, Jiangsu, 212013, China

Abstract

Enteric bacterial pathogens are a major threat to intestinal health. With the widespread use of antibiotics, bacterial resistance has become a problem, and there is an urgent need for a new treatment to reduce dependence on antibiotics. Butyrate can control enteric bacterial pathogens by regulating the expression of their virulence genes, promoting the posttranslational modification of their proteins, maintaining an anaerobic environment, regulating the host immune system and strengthening the intestinal mucosal barrier. Here, this review describes the mechanisms by which butyrate regulates the pathogenicity of enteric bacterial pathogens from various perspectives and discusses the prospects and limitations of butyrate as a new option for the control of pathogenic bacteria.

Funder

the National Natural Science Foundation of China

the Natural Science Research of Jiangsu Higher Education Institutions of China

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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