A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta-Reference-Cited by-同舟云学术

A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta

Published:2020-09 Issue:17 Volume:12 Page:1543-1558
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

A Eaves Lauren¹^ORCID,Phookphan Preeyaphan²^ORCID,E Rager Julia¹³⁴^ORCID,Bangma Jacqueline¹^ORCID,Santos Hudson P³⁵^ORCID,Smeester Lisa¹³^ORCID,O'Shea Thomas Michael⁶^ORCID,C Fry Rebecca¹³⁴⁶^ORCID

Affiliation:

1. Department of Environmental Sciences & Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

2. Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Laksi, Bangkok 10210, Thailand

3. Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

4. Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

5. School of Nursing, University of North Carolina, Chapel Hill, NC 27599, USA

6. Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

Abstract

Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequencing. Differential expression analysis was used to identify differences in the expression based on the sex of the fetus. Results: Sexually dimorphic expression was observed for 128 mRNAs and 59 miRNAs. A set of 25 miRNA master regulators was identified that likely contribute to the sexual dimorphic mRNA expression. Conclusion: These data highlight sex-dependent miRNA and mRNA patterning in the placenta and provide insight into a potential mechanism for observed sex differences in outcomes.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0062

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