High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome-Reference-Cited by-同舟云学术

High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome

Published:2021-03 Issue:6 Volume:13 Page:423-436
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Braga Aécio A¹^ORCID,Bortolin Raul H¹^ORCID,Graciano-Saldarriaga Magda E¹^ORCID,Hirata Thiago DC¹^ORCID,Cerda Alvaro²^ORCID,de Freitas Renata CC¹^ORCID,Lin-Wang Hui T³^ORCID,Borges Jessica B³^ORCID,França João ID⁴^ORCID,Masi Laureane N⁵^ORCID,Curi Rui⁵^ORCID,Pithon-Curi Tania C⁵^ORCID,Sampaio Marcelo F⁶⁷^ORCID,Castro Lara R⁶⁷^ORCID,Bastos Gisele M³⁸^ORCID,Hirata Rosario DC¹^ORCID,Hirata Mario H¹^ORCID

Affiliation:

1. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil

2. Department of Basic Sciences, Center of Excellence in Translational Medicine, CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile

3. Molecular Research Laboratory in Cardiology, Institute Dante Pazzanese of Cardiology, Sao Paulo 04012-909, Brazil

4. Laboratory of Epidemiology and Statistics, Institute Dante Pazzanese of Cardiology, Sao Paulo 04012-909, Brazil

5. Interdisciplinary Post-graduate Program in Health Sciences, Cruzeirodo Sul University, Sao Paulo 01506-000, Brazil

6. Medical Clinic Division, Institute Dante Pazzanese of Cardiology, Sao Paulo 04012-909, Brazil

7. Department of Cardiology, Real e Benemerita Associação Portuguesa de Beneficiência, Sao Paulo 01323-001, Brazil

8. Department of Teaching and Research, Real e Benemerita Associação Portuguesa de Beneficiencia, Sao Paulo 01323-001, Brazil

Abstract

Aim: To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). Methods: Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were validated in a larger cohort (MetS, n = 89; non-MetS, n = 144). Results: In the screening study, seven miRNAs were dysregulated in patients with MetS, and miR-421 remained increased in the validation study. miR-421 was associated with a high risk of MetS and insulin resistance and hypertension and correlated with glycated hemoglobin, triacylglycerols, high-sensitivity CRP, IL-6, resistin and adiponectin (p < 0.05). Conclusion: Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS.

Funder

Comisión Nacional de Investigación Científica y Tecnológica

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2020-0247

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1. Cardiovascular consequences of metabolic syndrome