Влияние триметазидина на метаболизм L-аргинина в лейкоцитах и панкреасе в АС- режиме химиотерапии

Abstract

The AC-chemotherapy regimen had a cardiotoxic effect in healthy rats associated with body weight loss. At the same time, lipid peroxidation (LPO) processes and arginase activity are stimulated, and production of bioavailable nitric oxide (NO) in leukocytes and pancreas decreases which may be involved in (DOX-CY)-induced cardiovascular complications. Correlations were also observed between these metabolic parameters and body weight. Trimetazidine had a cardioprotective effect in the AC-chemotherapy regimen that correlated with the increase in body weight of animals. There was found a regulatory effect of the drug on LPO processes, arginase activity, and bioavailable NO production, which were simultaneously correlated with weight changes and can participate in the drug’s pleiotropic and systemic effects and clinical efficacy.