Association of polymorphism of the glutathione-s-transferase M1 gene and tumor necrosis factor alpha with the formation and size of decay cavities in patients with pulmonary tuberculosis-Reference-Cited by-同舟云学术

Association of polymorphism of the glutathione-s-transferase M1 gene and tumor necrosis factor alpha with the formation and size of decay cavities in patients with pulmonary tuberculosis

Published:2024-09-06 Issue:2 Volume:16 Page:78-84
ISSN:2077-9828
Container-title:HIV Infection and Immunosuppressive Disorders
language:
Short-container-title:VIČ-infekc. immunosupr.

Author:

Alymenko M. A.¹^ORCID,Kolchanova N. E.²^ORCID,Valiev R. Sh.³^ORCID,Valiev N. R.³^ORCID,Balobanova N. P.⁴^ORCID,Gavrilyuk E. V.⁵^ORCID,Polonikov A. V.⁵^ORCID,Kolomietz V. M.⁵^ORCID,Mal G. S.⁵^ORCID,Ragulina V. A.⁵^ORCID,Safono Ya. A.⁴^ORCID

Affiliation:

1. University «Synergy»; Kazan State Medical Academy — branch of the institution of Additional Professional Education of the Russian Medical Academy of Continuing Professional Education

2. Gomel State Medical University

3. Kazan State Medical Academy — branch of the institution of Additional Professional Education of the Russian Medical Academy of Continuing Professional Education

4. University «Synergy»

5. Kursk State Medical University

Abstract

The aim. To study the association of polymorphic variants of the GSTM1 (E/D) and TNF-s (308G>A (rs1800629) genes with the formation of decay cavity sizes in patients with pulmonary tuberculosis.Material and methods. The study group is represented by 335 patients suffering from pulmonary tuberculosis (212 people were diagnosed with pulmonary tuberculosis for the ﬁrst time; 123 people with chronic pulmonary tuberculosis) aged 18 to 65 years; receiving an intensive phase of chemotherapy. To conduct molecular genetic studies; 335 people had whole blood taken from a vein into a test tube with EDTA. Genomic DNA was isolated using Arrow Blood DNA 500 reagent kits from whole blood (at the NorDiag Arrow station). After; the polymerase chain reaction was staged in real time using sets of reagents for genotyping SNPs: GSTM1 (E/D) and TNF-s (–308G>A (rs1800629).Results and discussion. In patients with pulmonary tuberculosis; the genotype DD of the gene GSTM1 (E/D) and the genotype GG of the gene TNF-s –308G>A (rs1800629) is most often associated with the formation of the size of decay cavities.Conclusion. It is advisable to introduce genotyping of the GSTM1 and TNF-s genes into the practice of a phthisiologist in order to predict the probability of the formation of the size of decay cavities in patients with pulmonary tuberculosis.

Publisher

Baltic Medical Education Center

Reference15 articles.

1. Belushkina N.N., Chemezov A.S., Paltsov M.A. Genetic studies of multifactorial diseases in the concept of personalized medicine. Preventive medicine, 2019, Vol. 3, рр. 26–29 (In Russ.).

2. Michael L., Scott M. Catherine M. Unusual Biotransformation Reactions of Drugs and Drug Candidates. Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches // Infection Genetic Evolution. 2020. Vol. 81. Р. 104204. doi: 10.1016/j.meegid.2020.104204.

3. Emre M. Unusual Biotransformation Reactions of Drugs and Drug Candidates // Drug Metab. Dispos. 2023. Vol. 51, No. 4. Р. 413–426. doi: https://doi.org/10.1124/dmd.121.000744.

4. Churina E.G., Urazova O.I., Sitnikova A.V., Novitsky B.B., Kononova T.E., Chumakova S.P., Patysheva M.R. Differentiation of blood monocytes and features of cytokine status in patients with pulmonary tuberculosis. Pathological physiology and experimental therapy, 2020, Vol. 64, No. 4, рр. 79–87 (In Russ.). doi: 0.25557/0031-2991.2020.04.79-87.

5. Lin Q., Chen X., Dai X. The association of cytokine gene polymorhpism with tuberculosis susceptibility in several regional populations // Cytokine. 2022. Р. 1–14. doi: 10.10162022.155915.