Comprehensive Study of Chalcone Derivatives

Abstract

Chalcones are flavonoid molecules that exist naturally and are essentially plant substances. These are the chemical compounds that have demonstrated a variety of intriguing biological actions with therapeutic potential against a variety of ailments. Anthranilic acid and orthophenylene diamine combine to produce benzimidazole. Additionally, the benzimidazole acetylated product goes via Claisen-Schmidt condensation with aryl aldehyde to create the respective chalcones. Due to phenolic groups and the existence of α, β unsaturated carbonyl groups, naturally occurring chalcones are polyhydroxylated in the aryl ring and exhibit a variety of biological activities, including antioxidant, antibacterial, antiinflammatory, and anticancer properties. Being natural precursors, chalcones are intermediates that are crucial for the synthesis of flavones. This review article emphasizes on the informative aspects, methods of synthesis, biological activities and applications of Chalcones.