Effectiveness and Safety of Antiobesity Medications in Patients With Obesity and Inflammatory Bowel Disease-Reference-Cited by-同舟云学术

Effectiveness and Safety of Antiobesity Medications in Patients With Obesity and Inflammatory Bowel Disease

Published:2023-10-09 Issue: Volume: Page:
ISSN:0002-9270
Container-title:American Journal of Gastroenterology
language:en
Short-container-title:Am J Gastroenterol

Author:

Pham Jonathan T.¹^ORCID,Ghusn Wissam²³^ORCID,Acosta Andres²³^ORCID,Loftus Edward V.²^ORCID,Johnson Amanda M.²

Affiliation:

1. Department of Internal Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA;

2. Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA;

3. Precision Medicine for Obesity Program, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Abstract

INTRODUCTION: Limited data exist evaluating antiobesity medications (AOM) in patients with inflammatory bowel disease (IBD). METHODS: We performed a case-control study evaluating the effectiveness and safety of AOM in patients with IBD with obesity, matched to non-IBD controls. RESULTS: After 12 months, the case (n = 36) and control (n = 36) groups achieved similar percent total body weight loss of −6.9 ± 8.3 and −8.1 ± 7.0 (P = 0.30), respectively. Side effect profiles were similar between groups. Seven patients experienced an IBD flare, all managed medically. DISCUSSION: AOM use in patients with IBD demonstrated similar effectiveness and safety when compared with that observed in the non-IBD population.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

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