Changes in Therapy Are Not Associated with Increased Remission in Patients with Crohn’s Disease of the Pouch-Reference-Cited by-同舟云学术

Changes in Therapy Are Not Associated with Increased Remission in Patients with Crohn’s Disease of the Pouch

Published:2023-11-17 Issue: Volume: Page:
ISSN:0002-9270
Container-title:American Journal of Gastroenterology
language:en
Short-container-title:Am J Gastroenterol

Author:

Kayal Maia¹,Deepak Parakkal²^ORCID,Beniwal-Patel Poonam³,Raffals Laura⁴,Dubinsky Marla⁵^ORCID,Chang Shannon⁶^ORCID,Higgins Peter D.R.⁷,Jiang Yue⁸^ORCID,Cross Raymond K.⁹^ORCID,Long Millie D.¹⁰,Herfarth Hans H.¹⁰^ORCID,Barnes Edward L.¹⁰^ORCID

Affiliation:

1. Division of Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, NY

2. Division of Gastroenterology, Washington University School of Medicine in St. Louis, St. Louis, MO

3. Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI

4. Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN

5. Division of Pediatric Gastroenterology, The Icahn School of Medicine at Mount Sinai, New York, NY

6. Division of Gastroenterology and Hepatology, NYU Langone Health, New York, NY

7. Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI

8. Trinity College of Arts and Sciences, Duke University, Durham, NC

9. Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD

10. Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC

Abstract

Background: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn’s Disease of the Pouch (CDP). Methods: This was a prospective, multicenter study evaluating the primary outcome of remission at 12 months of therapy for CDP. Results: 134 patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12-months. Of these, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status. Conclusion: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, the majority of whom did so without a change in therapy.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

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