Racial and Ethnic Disparities in Years of Potential Life Loss Among Patients With Cirrhosis During the COVID-19 Pandemic in the United States

Author:

Zhao Yunyu1,Yeo Yee Hui2,Samaan Jamil2,Lv Fan3,He Xinyuan1,Liu Jinli4,Li Mei1,Gao Ning1,Park Justin5,Yang Ju Dong26,Ayoub Walid S.26,Zhang Lei478,Odden Michelle C.9,Ji Fanpu11011,Nguyen Mindie H.912ORCID

Affiliation:

1. Department of Infectious Diseases, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PRC;

2. Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA;

3. School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, PRC;

4. China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Centre, Xi'an, Shaanxi, PRC;

5. David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA;

6. Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA;

7. Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia;

8. Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia;

9. Department of Epidemiology and Population Health, Stanford University Medical Center, Palo Alto, California, USA;

10. Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PRC;

11. Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, PRC;

12. Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA.

Abstract

INTRODUCTION: Our aim was to evaluate the impact of race/ethnicity on cirrhosis-related premature death during the COVID-19 pandemic. METHODS: We obtained cirrhosis-related death data (n = 872,965, January 1, 2012–December 31, 2021) from the US National Vital Statistic System to calculate age-standardized mortality rates and years of potential life lost (YPLL) for premature death aged 25–64 years. RESULTS: Significant racial/ethnic disparity in cirrhosis-related age-standardized mortality rates was noted prepandemic but widened during the pandemic, with the highest excess YPLL for the non-Hispanic American Indian/American Native (2020: 41.0%; 2021: 68.8%) followed by other minority groups (28.7%–45.1%), and the non-Hispanic White the lowest (2020: 20.7%; 2021: 31.6%). COVID-19 constituted >30% of the excess YPLLs for Hispanic and non-Hispanic American Indian/American Native in 2020, compared with 11.1% for non-Hispanic White. DISCUSSION: Ethnic minorities with cirrhosis experienced a disproportionate excess death and YPLLs in 2020–2021.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Gastroenterology,Hepatology

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