Modern approaches to the treatment of Cushing’s disease

Abstract

Traditionally the Cushing’s disease (CD) is considered a rare disease. Since 2012 СD has the official status of an orphan disease in the Russian Federation. Now prevalence of this disease in the world are from 1,5 to 3,9 cases of CD on 1 million people of the population. The reason of CD is the adenoma of a hypophysis (сortiсotropinoma). The “gold” standard of therapeutic tactics of patients with CD is the transsphenoidal surgery. However in 20% of cases after the radical treatment  fail to achieve remission of pathological process. Now in an arsenal of the neuroendocrinologist we have various methods of  therapy, including various methods of drug therapy. The focus of  preparations are central type action:  analogs of a somatostatin. The representative of this group of preparations is Pasireotid who has proved the efficiency by results of the multicenter clinical trials. This review  focuses of the current   state of knowledge about methods of treatment of CD, about new therapeutic opportunities with application of analogs of a somatostatin.