Influence of gut-microbiota on breast cancer development and management
Author:
Bhaskar Pranav1, Attri Sampan2, Sharma Anita3, Bisht Shiwali4
Affiliation:
1. Department of Biochemistry, Panjab University, Chandigarh - 160014, India 2. Viral Testing Facility, Forensic Science Laboratory Punjab, Phase IV, SAS Nagar (Mohali)-160059, India 3. Viral Testing Facility, Forensic Science Laboratory Punjab, Phase IV, SAS Nagar (Mohali)-160059, India. University Institute of Applied and Health Sciences, Chandigarh University, Mohali, Punjab, India. 4. Department of Science, Motherhood University, Bhagwanpur, Karaundi – 247661, Uttarakhand, India.
Abstract
Despite all existing diagnostic and treatment options, breast cancer remains a leading cause of morbidity and mortality among women. Breast cancer is linked to estrogen metabolism and obesity, influenced by gut microbes. The gut microbiota constantly interacts with the host, causing local and distant impacts. Several bacterial genes can generate estrogen-metabolizing enzymes affecting estrogen levels in the blood. On the other hand, estrogen-like substances may promote the growth of certain bacterial species. These bacterial species produce cancer-fighting products such as butyrate, lithocholic acid, and cadaverine. The gut microbiota composition and metabolites could be exploited as breast cancer indicators. These correlations propose that the microbiota of the gut is a utile starting point for novel approaches to diagnose and treat the disease. This chapter examines the factors that change the typical composition of the gut-microbiota and our growing understanding of how the microbiota affects the onset of breast cancer. Additionally, the crucial features of the human microbiota are revealed in this chapter, which may aid in developing novel strategies for the detection, treatment, and prevention of breast cancer.
Publisher
The Applied Biology & Chemistry Journal
Subject
Community and Home Care,Marketing,Organizational Behavior and Human Resource Management,Strategy and Management,Drug Discovery,Pharmaceutical Science,Pharmacology,General Medicine,General Medicine,General Medicine,General Medicine,General Medicine,General Earth and Planetary Sciences,General Environmental Science,General Earth and Planetary Sciences,General Environmental Science,General Medicine
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