Single-nucleotide polymorphisms of the IL-12 gene lead to a higher cancer risk: a meta-analysis based on 22,670 subjects

Author:

Shi Xiaohan12,Jia Yingxian12,Xie Xiaochuan3,Li Shangwei12

Affiliation:

1. Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University

2. Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University

3. Department of Cardiology, West China Hospital, Sichuan University

Publisher

Genetics Society of Japan

Subject

Genetics,Molecular Biology,General Medicine

Reference55 articles.

1. Amirzargar, A. A., Bagheri, M., Ghavamzadeh, A., Alimoghadam, K., Khosravi, F., Rezaei, N., Moheydin, M., Ansaripour, B., Moradi, B., and Nikbin, B. (2005) Cytokine gene polymorphism in Iranian patients with chronic myelogenousleukaemia. Int. J.Immunogenet. 32, 167–171.

2. BenChaaben, A., Busson, M., Douik, H., Boukouaci, W., Mamoghli, T., Chaouch, L., Harzallah, L., Dorra, S., Fortier, C., Ghanem, A., et al. (2011) Association of IL-12p40 +1188 A/C polymorphism with nasopharyngeal cancer risk and tumor extension. Tissue Antigens 78, 148–151.

3. Cavallo, F., Quaglino, E., Cifaldi, L., Di Carlo, E., André, A., Bernabei, P., Musiani, P., Forni, G., and Calogero, R. A. (2001) Interleukin 12-activated lymphocytes influence tumor genetic programs. Cancer Res. 61, 3518–3523.

4. Chen, X., Han, S., Wang, S., Zhou, X., Zhang, M., Dong, J., Shi, X., Qian, N., Wang, X., Wei, Q., et al. (2009) Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women. Clin. Cancer Res. 15, 400–405.

5. Croxford, A. L., Kulig, P., and Becher, B. (2014) IL-12-and IL-23 in health and disease. Cytokine Growth Factor Rev. 25, 415–421.

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