Reperfusion in acute pulmonary thromboembolism

Author:

Fernandes Caio Julio Cesar dos Santos1ORCID,Jardim Carlos Vianna Poyares2ORCID,Alves Jr José Leonidas1ORCID,Oleas Francisca Alexandra Gavilanes2ORCID,Morinaga Luciana Tamie Kato2ORCID,Souza Rogério de2ORCID

Affiliation:

1. Universidade de São Paulo, Brazil; Universidade de São Paulo, Brazil

2. Universidade de São Paulo, Brazil

Abstract

ABSTRACT Acute pulmonary thromboembolism (APTE) is a highly prevalent condition (104-183 cases per 100,000 person-years) and is potentially fatal. Approximately 20% of patients with APTE are hypotensive, being considered at high risk of death. In such patients, immediate lung reperfusion is necessary in order to reduce right ventricular afterload and to restore hemodynamic stability. To reduce pulmonary vascular resistance in APTE and, consequently, to improve right ventricular function, lung reperfusion strategies have been developed over time and widely studied in recent years. In this review, we focus on advances in the indication and use of systemic thrombolytic agents, as well as lung reperfusion via endovascular and classical surgical approaches, in APTE.

Publisher

FapUNIFESP (SciELO)

Subject

Pulmonary and Respiratory Medicine

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