Effect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic syndrome model

Author:

Cavdar Sibel1ORCID,Acar Alev Garip2ORCID,Camyar Asuman3ORCID,Hür Ender4ORCID,Sozmen Eser Yıldırım5ORCID,Sen Sait5ORCID,Ozısık Melih6ORCID,Akcay Yasemin Delen5ORCID,Duman Elif7ORCID,Gönen Sena5ORCID,Akcicek Fehmi1ORCID,Duman Soner1ORCID

Affiliation:

1. Ege University, Turkey

2. Izmir Atatürk Training and Research Hospital, Turkey

3. Izmir Çiğli Training and Research Hospital, Turkey

4. Uşak University Medical Faculty Hospital, Turkey

5. Ege University Medical Faculty Hospital, Turkey

6. Izmir Tepecik Training and Research Hospital, Turkey

7. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Turkey

Abstract

Abstract Introduction: Nephrotic syndrome (NS) is one of the reasons of end-stage kidney disease, and elucidating the pathogenesis and offer new treatment options is important. Oxidative stress might trigger pathogenesis systemically or isolated in the kidneys. Octreotide (OCT) has beneficial antioxidant effects. We aimed to investigate the source of oxidative stress and the effect of OCT on experimental NS model. Methods: Twenty-four non-uremic Wistar albino rats were divided into 3 groups. Control group, 2 mL saline intramuscular (im); NS group, adriamycin 5 mg/kg intravenous (iv); NS treatment group, adriamycin 5 mg/kg (iv) and OCT 200 mcg/kg (im) were administered at baseline (Day 0). At the end of 21 days, creatinine and protein levels were measured in 24-hour urine samples. Erythrocyte and renal catalase (CAT) and thiobarbituric acid reactive substance (TBARS) were measured. Renal histology was also evaluated. Results: There was no significant difference among the 3 groups in terms of CAT and TBARS in erythrocytes. Renal CAT level was lowest in NS group, and significantly lower than the control group. In treatment group, CAT level significantly increased compared with NS group. In terms of renal histology, tubular and interstitial evaluations were similar in all groups. Glomerular score was significantly higher in NS group compared with control group and it was significantly decreased in treatment group compared to NS group. Conclusions: Oxidative stress in NS might be due to the decrease in antioxidant protection mechanism in kidney. Octreotide improves antioxidant levels and histology in renal tissue and might be a treatment option.

Publisher

FapUNIFESP (SciELO)

Subject

General Medicine

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