AN EXPERIENCE ON LIVING DONOR LIVER TRANSPLANTATION FOR COLORECTAL LIVER METASTASIS IN SOUTH AMERICA: A NEW ERA IN TRANSPLANT ONCOLOGY

Author:

Fernandes Eduardo de Souza Martins1ORCID,Souza Gabrielle Oliveira de1ORCID,Braga Eduardo Pinho1ORCID,Furtado Rodrigo Lopes Leite1ORCID,Corrêa Raphael Rodrigues1ORCID,Queiroz Camila Tobias1ORCID,Mello Felipe Pedreira Tavares de1ORCID,Girão Camila Liberato1ORCID,Line Pal-Dag2ORCID,Torres Orlando Jorge Martins3ORCID

Affiliation:

1. Universidade Federal do Rio de Janeiro, Brazil

2. Oslo University Hospital, Norway

3. Universidade Federal do Maranhão, Brazil

Abstract

ABSTRACT BACKGROUND: Complete surgical resection is the treatment of choice for patients with liver metastases, but in some patients, it is not possible to obtain a complete R0 resection. Moreover, the recurrence rate is up to 75% after three years. After the experience of the Oslo group with cadaveric liver transplant, some centers are starting their experience with liver transplant for colorectal liver metastasis. AIMS: To present our initial experience with living donor liver transplant for colorectal liver metastasis. METHODS: From 2019 to 2022, four liver transplants were performed in patients with colorectal liver metastases according to the Oslo criteria. RESULTS: Four patients underwent living donor liver transplants, male/female ratio was 3:1, mean age 52.5 (42–68 years). All patients were included in Oslo criteria for liver transplant. Two patients had already been submitted to liver resection. The decision for liver transplant occurred after discussion with a multidisciplinary team. Three patients recurred after the procedure and the patient number 3 died after chemotherapy. CONCLUSIONS: Living donor liver transplant is a viable treatment option for colorectal liver metastasis in Brazil, due to a shortage of donors.

Publisher

FapUNIFESP (SciELO)

Subject

General Medicine

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