Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice

Author:

Aoki Caio Tavares1,Moura Rodrigo Andrade1,Ferreira Luana Assis1,Mendes Mariana Garcia1ORCID,Santos Duana Carvalho1,Rezende Marcio Junior1,Gomez Marcus Vinícius1ORCID,Castro-Junior Célio José1ORCID

Affiliation:

1. Graduate Program in Health Sciences, Brazil

Publisher

FapUNIFESP (SciELO)

Subject

Infectious Diseases,Toxicology,Animal Science and Zoology,Parasitology

Reference28 articles.

1. Pain modulatory properties of Phoneutria nigriventer crude venom and derived peptides: a double-edged sword;Lauria PSS;Toxicon,2020

2. Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6;Vieira LB;J Pharmacol Exp Ther,2005

3. The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice;Tonello R;Br J Pharmacol,2017

4. Analgesic and side effects of intravenous recombinant Phα1β;Rigo FK;J Venom Anim Toxins incl Trop Dis,2020

5. Cancer pain: where are we now?;Magee David;Pain Manag,2019

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