Affiliation:
1. Universidade Federal do Espírito Santo, Brasil
2. Universidade Federal do Rio de Janeiro, Brasil
Abstract
Abstract Objectives: to identify the scientific evidence on excessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: “What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in pediatric patients?”. The research used the descriptors: “extensively drug-resistant tuberculosis” OR “multidrug-resistant tuberculosis” AND “pediatrics”. The research was carried out in a double-blind manner in the following databases of the Medical Literature Analysis and Retrieval System Online, Regional Office for the Western Pacific’s Institutional Repository for Information Sharing, Embase/Elsevier and International Clinical Trials Registry Platform, with a temporal cut-off from 2011 to 2021, sending a final synthesized sample of 18 articles, which evaluated the methodological content through the level of evidence. Results: the results show the lack of research with a high level of evidence related to MDR-TB in children, the lack of adequate dosage of second-line drugs for the pediatric population and the importance of drug sensitivity testing for the cases of treatment Conclusions: it was identified that the obstacles to MDR-TB treatment were concentrated in the lack of detailed protocols, safe drug dosages with a low side effect, and mainly in the social health determinants and disease process involving MDR-TB.
Subject
Public Health, Environmental and Occupational Health,Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Reference47 articles.
1. Global Tuberculosisis Report 2020,2020
2. Boletim Epidemiológico Tuberculose 2021,2021
3. Management of multidrug-resistant tuberculosis with shorter treatment regimen in Niger: nationwide programmatic achievements;Piubello A;Respir Med,2020
4. Management of drug-resistant tuberculosis;Lange C;Lancet,2019
5. Predicted impact of the COVID-19 pandemic on global tuberculosis deaths in 2020;Glanziou P.;Medrxiv,2020