Abstract
Human papillomavirus (HPV)infection consists the majority of cervical precancerous lesions and cancers. Various screening programmes aim in indentifying HPV infection and preventing cervical cancer. We present a 20-year-old female patient whose first pap smear revealed atypical squamous cells of undetermined significance (ASCUS). Pap smear, followed by genotyping evaluation, revealed high-risk HPV 33 infiltration. Colposcopy and cervical biopsies were performed due to suspicious cervical lesions, revealing cervical intraepithelial neoplasia grade II and focal high grade squamous intraepithelial lesion.(Grade III.) Patient underwentloop electrosurgical excision procedure (LEEP) due to assiduous imaging findings. Histopathologic establishment revealed anatomic areas of CIN III. (Cervical Intraepithelial Neoplasia) Aim of our study represents proper diagnosis and therapeutic mapping of a juvenile high grade cervical intraepithelial lesion, depending always on fertility preservation.