Abstract
Background: Hair graying is a common sign of aging resulting from complex regulation of melanogenesis. It occurs due to many factors, including age, oxidative stress, psychological stress, and malnutrition. Objective: Assessment of safety and effectiveness of an anti-gray hair product when applied to healthy adult human subjects having partially gray hair. Methods: Total 32 subjects, aged 20 to 55 years, were initially enrolled and 29 subjects successfully completed the study, which spanned a total of five visits over 120 days. The subjects were provided with ThriveCo® Hair Prime Serum as test product and adjunct shampoo to use at home. Hair serum was evenly distributed across scalp and gently massaged into the hair roots. Primary evaluations included reduction in hair graying, improvement in hair growth, and Graying Severity Score (GSS) for reduction in graying severity. Results: After 120 days of treatment, the GSS exhibited a significantly decrease (p-value <0.01) to 7.00, indicating significant effect of the hair serum in reducing severity of hair graying. Additionally, a substantial improvement (p-value <0.01) in hair growth was observed, with 86.57% and 13.41% of hairs in the anagen (A) stage and telogen (T) stage respectively (A:T ratio= 6:1). Image-Pro analysis using the L* value demonstrated marked improvement of 6.19% on Day 120 from baseline Day 01, further indicating the anti-graying effect of the hair serum. Furthermore, all the subjects experienced visible enhancement in general appearance of hair and scalp. None of the subjects experienced any adverse events during entire study duration. Conclusion: Test product ThriveCo® Hair Prime Serum containing Arcedin™ demonstrated efficacy and tolerability in reversing the hair graying. Furthermore, following a 120-day usage, this hair serum demonstrated significant enhancements in hair growth, visual appearance, and strength, solidifying its potential as a beneficial addition to a comprehensive daily hair care regimen.