Altered element homeostasis and transmethylation ability in short-term polyphenol rich supplementation in hyperlipidemic animal model

Author:

Hagymási K.1ORCID,Szentmihályi K2,May Z.2,Sárdi É.3,Fébel H.4,Kocsis I.5,Blázovics A.6

Affiliation:

1. Department of Surgery, Transplantology and Gastroenterology, Semmelweis University, Üllői út 78., H-1082, Budapest, Hungary

2. Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar tudósok körútja 2., H-1117, Budapest, Hungary

3. Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Ménesi út 44., H-1118, Budapest, Hungary

4. Institute of Animal Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Gesztenyés út 1., H-2053, Herceghalom, Hungary

5. Department of Laboratory Medicine, Semmelweis University, Üllői út 78/a., H-1089, Budapest, Hungary

6. Department of Surgical Research and Techniques, The Heart and Vascular Center, Semmelweis University, Nagyvárad tér 4., H-1089, Budapest, Hungary

Abstract

Abstract Non-alcoholic fatty liver disease is one of the most common chronic liver diseases with unclarified pathomechanism and without evidence-proven therapy. Dietary polyphenols, targeting oxidative stress, are at the center of investigations. Our aim was to examine the effects of a polyphenol rich extract on metal element homeostasis and transmethylation ability in non-alcoholic fatty liver model. A ten-day rat model was used (control group, hyperlipidemic group with fat-rich diet, hyperlipidemic group with fat-rich diet and polyphenol supplementation, N = 8 in each group). The hyperlipidemic diet increased the concentration of the majority of the elements with significantly higher contents of B, Co, Cu, Fe, Mg, Mn, Na, Ni, P, Se, Si, and Zn in the liver. Further elevation of Al, Pb, and Sn concentrations could be observed in polyphenol supplemented animals. The polyphenol supplement unexpectedly decreased the transmethylation ability of the liver (132.00 vs. 114.15 vs. 92.25 HCHO μg g−1) further. The results emphasize the possible role of altered metal and non-metal element concentrations and decreased transmethylation ability in the pathomechanism of fatty liver disease. Dietary supplementation with natural compounds may have undesirable effect as well, there is the necessity to improve the efficacy of polyphenol formulations because of their low oral bioavailability.

Publisher

Akademiai Kiado Zrt.

Subject

Food Science

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