OBSERVATION OF THE PREDICTIVE VALUE OF ON MCP-1 THE CURATIVE EFFECT OF PERIODONTITIS PATIENTS AFTER TREATMENT AND ANALYSIS OF THE RISK FACTORS AFFECTING THE EFFICACY

Yu Ye*, Yi Qin

Department of Stomatology, Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital, Nanning, 530000, Guangxi Zhuang Autonomous Region, China

Objective: In order to study the predictive value of monocyte chemoattractant protein-1 (MCP-1) for periodontitis patients after treatment and the risk factors affecting the efficacy.

Method: 20 patients with chronic periodontitis and 10 patients with dental health were selected as the study samples to ex- plore the difference between the healthy control group in terms of expression level of MCP-1, plaque index (PLI), gingival index, hemorrhage index, attachment loss and depth of visit in periodontitis patients before and after treatment.

Results: The results showed that the concentration of MCP-1 in gingival crevicular fluid (GCF) of patients with chronic periodontitis was significantly higher than that of healthy people. The concentration of MCP-1 in GCF of patients with chronic periodontitis decreased significantly after basic periodontal treatment, and the clinical indicators also changed significantly after basic treatment. It is proved that the change of MCP-1 concentration may reflect the severity and progress of chronic periodontitis. It can be used as an index to judge the clinical stage of chronic periodontitis and provide a theoretical basis for the prevention and treatment of chronic periodontitis.

Conclusion: The shortcoming of this experiment is that there are fewer samples. If the sample size can be increased and the error in future clinical experiments can be reduced, more accurate results will be obtained.