CHANGES IN LEVELS OF SERUM S-CHE AND APACHE II AND THEIR EFFECTS ON PROGNOSIS BEFORE DEATH IN PATIENTS WITH SEVERE PNEUMONIA

CHUNLONG ZHAGN, XUDONG PENG#, DEZHONG LI, ZHENWU ZOU, FAWEI ZHOU, XIANGYANG HU

Department of Emergency, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture

Objective: To analyse the changes in serum S-ChE and APACHE II in patients with pneumonia before their death.

Methods: There were 118 patients with severe pneumonia between October 2016 and October 2018 who were selected. According to the mortality rate within 28 days of diagnosis, the patients were divided into a survival group (83 cases) and deceased group (35 cases). The differences in serum S-ChE levels and the acute physiology and chronic health (APACHE II) score between the two groups were compared. Logistic analysis was used to analyse the independent risk factors affecting the prognosis of patients with critical pneumonia.

Results: The serum S-ChE content and oxygenation index in the deceased group were significantly lower than those in the surviving group (P<0.01), APACHE II score and MODS score were significantly higher in the deceased group than in the surviving group (P<0.01), and there was no significant difference between the two groups in other indexes (P>0.05). Logistic regression analysis showed that the serum S-ChE content, APACHE II score, CURB-65 score and MODS score were independent influencing factors associated with death (P<0.05). The 28-day survival rate of S-ChE >3.38 group was significantly higher than that of S-ChE <3.38 group (P<0.05).

Conclusion: The serum S-ChE level decreased and APACHE II increased in patients with severe pneumonia before death. Patients with lower S-ChE content had a poor prognosis.