EXPRESSION OF SMARCE1, CRISP3 AND NOP14 IN CERVICAL CANCER AND THEIR CORRELATION WITH CARCINOGENESIS

Caixia Liu¹, Aimei Shi^{2, *}

¹Department of Obstetrics and Gynecology, Yulin Second Hospital of Shaanxi Province, Yulin 719000, Shaanxi Province, China - ²Department of Obstetrics and Gynecology, Suzhou Mingji Hospital, Suzhou 215009, Jiangsu Province, China

Introduction: To detach the expression of SMARCE1, CRISP3 and NOP14 and their correlation with carcinogenesis.

Material and Method: A total of 100 cervical lesions treated in our hospital were divided into a control (CG) and observation (OG) groupbased on pathological results.IHC was used to check the SMARCE1, NOP14, and CRISP3 levelsin cervical tissues. SMARCE1, CRISP3 and NOP14 alone or in combination in CCA were analyzed to determine their diagnostic value.

Results: In the OG, SMARCE1, CRISP3 and NOP14 expressed at higher levels than in the OG. The TNM stage, lymph node metastasis, and age of patients with CCA showing expression of SMARCE1, CRISP3, and NOP14 were no difference; Patients with CCA of different differentiation degrees expressed SMARCE1, CRISP3 and NOP14 at significantly different levels, SMARCE1, CRISP3 and NOP14 proteins are expressed more frequently in tumors with a lower differentiation degree.OG serum CEA, CA125, and CA153 levels were higher than CG. SMARCE1, CRISP3 and NOP14 had AUC values of 0.807, 0.767, 0.834 and 0.867, respectively, according to ROC curve analysis.

Conclusion: In patients with CCA, SMARCE1, CRISP3 and NOP14 are expressed, and the lower the tumor differentiation, the more likely the expression is to be positive.Clinical diagnostic value for CCA is higher when SMARCE1, CRISP3 and NOP14 are detected together.