PREDICTIVE VALUE OF PDW AND PC ON THE PROGNOSIS OF PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER RECEIVING PLATINUM-CONTAINING CHEMOTHERAPY

Jian Wang¹, Lingxiang Liu², Guoqing Wang³, Xiaoguang Mi⁴, Xingxing Yin⁵, Mengting Shao⁶, Jia Fan⁷, Yiqian Liu^2,# Ling Zhang^{8, #}

¹Department of Oncology, Wuxi Second Geriatric Hospital, Wuxi, 214174, Jiangsu, China - ²Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China - ³Department of Traditional Chinese Medicine, The Fifth People's Hospital of Changshu, Changshu 215500, China - ⁴Department of Respiratory Medicine, The Fifth People's Hospital of Changshu, Changshu 215500, China - ⁵Department of Functional Inspection, The Fifth People's Hospital of Changshu, Changshu 215500, China - ⁶Department of Medical Oncology, The Fifth People's Hospital of Changshu, Changshu 215500, China - ⁷Department of General Medicine, Changshu First People's Hospital Affiliated to Soochow University, Changshu 215500, China - ⁸Department of Oncology, Jintan Hospital Affiliated to Jiangsu University, Changzhou, 213200, China

Objective: Platelet distribution width (PDW) and platelet count (PC) are frequently investigated platelet parameters in blood routine examination. We aimed to investigate the association of PDW and PC with the prognosis of patients with advanced non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy. 

Methods: Retrospective study analyzed 578 NSCLC patients who received platinum-based chemotherapy. Receiver operating characteristic (ROC) curve analysis estimated the optimal cut-off values of PDW and PC. Univariate and multivariate Cox regression analysis evaluated the influence of prognostic factors on prognosis. 

Results: ROC curve showed that optimal cut-off values of PDW and PC were 15.25 and 243. Squamous cell carcinoma, low differentiation, and high PDW were independent prognostic factors for poor PFS. Besides, low KPS score, squamous cell carcinoma, low differentiation, no mutation or unknown EGFR, high PDW, and high PC were independent risk factors for OS in NSCLC patients. When PC and PDW parameters were replaced by the coefficients of platelet count and PDW index (coPDW-PC) in multivariate analysis, the results revealed that a high coPDW-PC index was an independent risk factor for poor OS. 

Conclusion: A high coPDW-PC index may serve as a potential predictor of poor survival in advanced NSCLC patients receiving platinum-containing chemotherapy.