CORRELATION BETWEEN SCYL1-BP1 AND COX-2 PROTEIN EXPRESSION AND THE CLINICOPATHOLOGICAL PARAMETERS AND PROGNOSIS IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

Binghan Shen, Zhiming Cai, Yanling Wu, Gongping Huang, Xiaoyi Ye^*

Department of Respiratory Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, PR China

Objective: To analyze the correlation between SCYL1-BP1 and COX-2 protein expression and the clinicopathological parameters and prognosis in patients with non-small cell lung cancer (NSCLC).

Methods: A total of 82 pathological specimens were selected of lung cancer patients admitted to the oncology department of our hospital for surgical treatment from April 2015 to January 2016, and 30 samples of paracancerous lung tissue 4 to 5 cm away from the mass were taken as the control. The expression of SCYL1-BP1 and COX-2 proteins in the lung cancer tissues and paracancerous tissues were detected immunohistochemically, and the correlation was analyzed between the two proteins and clinicopathological parameters and prognosis.

Results: The positive expression rates of SCYL1-BP1 and COX-2 proteins in lung cancer tissue were significantly higher than those in paracancerous tissue (P<0.05). A significant correlation was found between SCYL1-BP1 expression and tumor differentiation, TNM stage, RRMI expression, and COX-2 expression (P<0.05). No significant correlation was found between SCYL1-BP1 expression and patient age, sex, pathological type, tumor diameter, or smoking history (P>0.05). SCYL1-BP1 expression was positively correlated with tumor differentiation (P<0.05), while SCYL1-BP1 expression was negatively correlated with TNM stage (P<0.05). SCYL1-BP1 was negatively correlated with RRMI expression (P < 0.05), and the expression of SCYL1-BP and COX-21 was negatively correlated (P<0.01). The median DFS in the SCYL1-BP1 high-expression group was longer than that in the SCYL1-BP1 low-expression group (P<0.05), and the postoperative median DFS in patients with adenocarcinoma was longer than that in patients with squamous cell carcinoma (P<0.05). High expression of SCYL1-BP1 and low expression of COX-2 prolonged postoperative DFS in lung cancer.

Conclusion: SCYL1-BP1 and COX-2 proteins are highly expressed in NSCLC and involved in the development, invasion, and metastasis of lung cancer. Combined detection of SCYL1-BP1 and COX-2 can be used as a potential index to judge the prognosis of NSCLC patients.