Author:
Cutrim Érico Murilo Monteiro,Neves Precil Diego Miranda de Meneses,Campos Marcos Adriano Garcia,Wanderley Davi Campos,Teixeira-Júnior Antonio Augusto Lima,Muniz Monique Pereira Rêgo,Ladchumananandasivam Francisco Rasiah,Gomes Orlando Vieira,Vasco Rafael Fernandes Vanderlei,Brito Dyego José de Araújo,Lages Joyce Santos,Salgado-Filho Natalino,Guedes Felipe Leite,de Almeida José Bruno,Magalhães Marcelo,Araújo Stanley de Almeida,Silva Gyl Eanes Barros
Abstract
Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by segmentar or global collapse of the glomerulus and hypertrophy and hyperplasia of podocytes. The Columbia classification of 2004 classified CG as a histological subtype of focal segmental glomerulosclerosis (FSGS). A growing number of studies have demonstrated a high prevalence of CG in many countries, especially among populations with a higher proportion of people with African descent. The present study is a narrative review of articles extracted from PubMed, Medline, and Scielo databases from September 1, 2020 to December 31, 2021. We have focused on populational studies (specially cross-sectional and cohort articles). CG is defined as a podocytopathy with a distinct pathogenesis characterized by strong podocyte proliferative activity. The most significant risk factors for CG include APOL1 gene mutations and infections with human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. CG typically presents with more severe symptoms and greater renal damage. The prognosis is notably worse than that of other FSGS subtypes.
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