Author:
Xiang Pan,Xu Xinmin,Lu Xin,Gao Lili,Wang Huizhu,Li Zhenpeng,Xiong Haofeng,Li Ruihong,Xiong Yanwen,Pu Lin,Qin Tian,Jin Fangfang,Ren Hongyu,Li Chuansheng,Yang Jing,Zhang Ming,Gong Jie,Chen Xiaoping,Zheng Han,Tan Jianbo,Sun Yao,Zhao Fei,Hou Xuexin,Liu Yufeng,Guo Hebing,Hao Jingjing,Kan Biao,Zhou Haijian,Wang Yajie,Liu Jingyuan
Abstract
We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. In future, along with nervous system assessment, the pathogen genome detection and other indicators are needed for studying possible nervous system infection of SARS-CoV-2.
Funder
National Science and Technology Major Project
National Mega Project on Major Infectious Disease Prevention
Cited by
10 articles.
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