Author:
Wang Daxi,Wang Yanqun,Sun Wanying,Zhang Lu,Ji Jingkai,Zhang Zhaoyong,Cheng Xinyi,Li Yimin,Xiao Fei,Zhu Airu,Zhong Bei,Ruan Shicong,Li Jiandong,Ren Peidi,Ou Zhihua,Xiao Minfeng,Li Min,Deng Ziqing,Zhong Huanzi,Li Fuqiang,Wang Wen-jing,Zhang Yongwei,Chen Weijun,Zhu Shida,Xu Xun,Jin Xin,Zhao Jingxian,Zhong Nanshan,Zhang Wenwei,Zhao Jincun,Li Junhua,Xu Yonghao
Abstract
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
Cited by
24 articles.
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