Author:
Ye Yongrong,Han Fei,Ma Maolin,Sun Qipeng,Huang Zhengyu,Zheng Haofeng,Yang Zhe,Luo Zihuan,Liao Tao,Li Heng,Hong Liangqing,Na Ning,Sun Qiquan
Abstract
Background: Delayed graft function (DGF) is a common complication after kidney transplantation (KT) with a poor clinical outcome. There are no accurate biomarkers for the early prediction of DGF. Macrophage migration inhibitory factor (MIF) release during surgery plays a key role in protecting the kidney, and may be a potential biomarker for predicting post-transplant renal allograft recovery.Methods: Recipients who underwent KT between July 2020 and December 2020 were enrolled in the study. Plasma MIF levels were tested in recipients at different time points, and the correlation between plasma MIF and DGF in recipients was evaluated. This study was registered in the Chinese Clinical Trial Registry (ChiCTR2000035596).Results: Intraoperative MIF levels were different between immediate, slowed, and delayed graft function groups (7.26 vs. 6.49 and 5.59, P < 0.001). Plasma MIF was an independent protective factor of DGF (odds ratio = 0.447, 95% confidence interval [CI] 0.264–0.754, P = 0.003). Combining plasma MIF level and donor terminal serum creatinine provided the best predictive power for DGF (0.872; 95%CI 0.795–0.949). Furthermore, plasma MIF was significantly associated with allograft function at 1-month post-transplant (R2 = 0.42, P < 0.001).Conclusion: Intraoperative MIF, as an independent protective factor for DGF, has excellent diagnostic performance for predicting DGF and is worthy of further exploration.
Funder
Foundation for Innovative Research Groups of the National Natural Science Foundation of China
Reference41 articles.
1. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant;Wolfe;N Engl J Med.,1999
2. Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQI™) conference;Abecassis;Clin J Am Soc Nephrology.,2008
3. Delayed kidney graft function: from mechanism to translation;Schröppel B Legendre;Kidney Int.,2014
4. Delayed graft function in the kidney transplant;Siedlecki;Am J Transplant.,2011
5. Delayed graft function: state of the art, November 10-11, 2000. Summit meeting, Scottsdale, Arizona, USA;Halloran;Am J Transplant.,2001
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