Epidemiology of porcine deltacoronavirus among Chinese pig populations in China: systematic review and meta-analysis

Abstract

Porcine deltacoronavirus (PDCoV) is a newly emerging and important porcine enteropathogenic coronavirus that seriously threatens the swine industry in China and worldwide. We conducted a systematic review and meta-analysis to access the prevalence of PDCoV infection in pig population from mainland China. Electronic databases were reviewed for PDCoV infection in pig population, and meta-analysis was performed to calculate the overall estimated prevalence using random-effect models. Thirty-nine studies were included (including data from 31,015 pigs). The overall estimated prevalence of PDCoV infection in pigs in China was 12.2% [95% confidence interval (CI), 10.2–14.2%], and that in Central China was 24.5% (95%CI, 16.1–32.9%), which was higher than those in other regions. During 2014–2021, the estimated prevalence of PDCoV infection was the highest in 2015 at 20.5% (95%CI, 10.1–31.0%) and the lowest in 2021 at 4.8% (95%CI, 2.3–7.3%). The prevalence of PDCoV infection in sows was 23.6% (95%CI, 15.8–31.4%), which was higher than those in suckling piglets, nursery piglets, and finishing pigs. The prevalence of PDCoV infection was significantly associated with sampling region, sampling year, pig stage, and clinical signs (diarrhea). This study systematically evaluated the epidemiology of PDCoV infection in Chinese pig population. The findings provide us with a comprehensive understanding of PDCoV infection and are beneficial for establishing new controlling strategies worldwide.