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Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent

  • Published:2020-07-14 Issue: Volume:8 Page:
  • ISSN:2296-634X
  • Container-title:Frontiers in Cell and Developmental Biology
  • language:
  • Short-container-title:Front. Cell Dev. Biol.

Author:

Xu Qifu,Liu Chunxi,Zang Jie,Gao Shuai,Chou C. James,Zhang Yingjie

Funder

Natural Science Foundation of Shandong Province

Key Technology Research and Development Program of Shandong

Publisher

Frontiers Media SA

Subject

Cell Biology,Developmental Biology

Reference29 articles.

1. Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress.;Akamatsu;Anticancer. Res.,2009

2. The molecular hallmarks of epigenetic control.;Allis;Nat. Rev. Genet.,2016

3. A Review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?;Bellingham;CNS Neurosci. Ther.,2011

4. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.;Falkenberg;Nat. Rev. Drug Discov.,2014

5. Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.;Giacomini;ACS Med. Chem. Lett.,2014

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