Author:
Yang Chunhua,Wei Mengna,Zhao Yanpu,Yang Zhanyi,Song Mengyao,Mi Jia,Yang Xiaoyong,Tian Geng
Abstract
Post-translational modification (PTM) has a significant impact on cellular signaling and function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell development, and viability. The dysregulation of PTM in β cells is clinically associated with the development of diabetes mellitus. Here, we summarized current findings on major PTMs occurring in β cells and their roles in insulin secretion. Our work provides comprehensive insight into understanding the mechanisms of insulin secretion and potential therapeutic targets for diabetes from the perspective of protein PTMs.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Taishan Scholar Foundation of Shandong Province
Subject
Cell Biology,Developmental Biology