Emerging roles of growth factors in osteonecrosis of the femoral head

Author:

Che Zhenjia,Song Yang,Zhu Liwei,Liu Tengyue,Li Xudong,Huang Lanfeng

Abstract

Osteonecrosis of the femoral head (ONFH) is a potentially disabling orthopedic condition that requires total hip arthroplasty in most late-stage cases. However, mechanisms underlying the development of ONFH remain unknown, and the therapeutic strategies remain limited. Growth factors play a crucial role in different physiological processes, including cell proliferation, invasion, metabolism, apoptosis, and stem cell differentiation. Recent studies have reported that polymorphisms of growth factor-related genes are involved in the pathogenesis of ONFH. Tissue and genetic engineering are attractive strategies for treating early-stage ONFH. In this review, we summarized dysregulated growth factor-related genes and their role in the occurrence and development of ONFH. In addition, we discussed their potential clinical applications in tissue and genetic engineering for the treatment of ONFH.

Funder

Department of Science and Technology of Jilin Province

Health Commission of Jilin Province

Publisher

Frontiers Media SA

Subject

Genetics (clinical),Genetics,Molecular Medicine

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