Author:
Jiang Qi,Li Zhaohuai,Tao Tianyu,Duan Runping,Wang Xianggui,Su Wenru
Abstract
Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases. Studies about the immunopathogenesis and treatment of uveitis are helpful to comprehend systemic autoimmune diseases, and delay the progression of systemic autoimmune diseases, respectively. Tumor necrosis factor-alpha (TNF-α), a pleiotropic cytokine, plays a pivotal role in intraocular inflammation based on experimental and clinical data. Evidence of the feasibility of using anti-TNF-α agents for uveitis management has increased. Although there are numerous studies on TNF-α in various autoimmune diseases, the pathological mechanism and research progress of TNF-α in uveitis have not been reviewed. Therefore, the objective of this review is to provide a background on the role of TNF-α in the immunopathogenesis of uveitis, as well as from bench to clinical research progress, to better guide TNF-α-based therapeutics for uveitis.
Subject
Pharmacology (medical),Pharmacology
Reference167 articles.
1. Historical Perspectives on Tumor Necrosis Factor and its Superfamily: 25 Years Later, a Golden Journey;Aggarwal;Blood.,2012
2. Human Tumor Necrosis Factor. Production, Purification, and Characterization;Aggarwal;J. Biol. Chem.,1985
3. Long-Term Outcomes of Treatment With Biological Agents in Eyes With Refractory, Active, Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis;Al-Janabi;Ophthalmology.,2020
4. TH17 Cells Contribute to Uveitis and Scleritis and Are Expanded by IL-2 and Inhibited by IL-27/STAT1;Amadi-Obi;Nat. Med.,2007
5. Anti-Inflammatory Effect of Dehydroxymethylepoxyquinomicin, a Nuclear Factor-Κb Inhibitor, on Endotoxin-Induced Uveitis in Rats In Vivo and In Vitro;Ando;Ocul. Immunol. Inflamm.,2020
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