Author:
Chanana Neha,Palmo Tsering,Sharma Kavita,Kumar Rahul,Shah Bhushan,Mahajan Sudhanshu,Palleda Girish M.,Gupta Mohit D.,Kukreti Ritushree,Faruq Mohammad,Thinlas Tashi,Graham Brian B.,Pasha Qadar
Abstract
Dexamethasone can be taken prophylactically to prevent hypobaric hypoxia-associated disorders of high-altitude. While dexamethasone-mediated protection against high-altitude disorders has been clinically evaluated, detailed sex-based mechanistic insights have not been explored. As part of our India-Leh-Dexamethasone-expedition-2020 (INDEX 2020) programme, we examined the phenotype of control (n= 14) and dexamethasone (n= 13) groups, which were airlifted from Delhi (∼225 m elevation) to Leh, Ladakh (∼3,500 m), India, for 3 days. Dexamethasone 4 mg twice daily significantly attenuated the rise in blood pressure, heart rate, pulmonary pressure, and drop in SaO2resulting from high-altitude exposure compared to control-treated subjects. Of note, the effect of dexamethasone was substantially greater in women than in men, in whom the drug had relatively little effect. Thus, for the first time, this study shows a sex-biased regulation by dexamethasone of physiologic parameters resulting from the hypoxic environment of high-altitude, which impacts the development of high-altitude pulmonary hypertension and acute mountain sickness. Future studies of cellular contributions toward sex-specific regulation may provide further insights and preventive measures in managing sex-specific, high-altitude–related disorders.
Funder
Cardiovascular Medical Research and Education Fund
Subject
Pharmacology (medical),Pharmacology
Cited by
2 articles.
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