Author:
Silva Jéssica Manoelli Costa,Teixeira Eliel Barbosa,Mourão Ronald Matheus da Silva,Ferraz Rafaella Sousa,Moreira Fabiano Cordeiro,Assumpção Paulo Pimentel de,Calcagno Danielle Queiroz
Abstract
Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.
Funder
Pró-Reitoria de Pesquisa e Pós-Graduação, Universidade Federal do Pará
Subject
Pharmacology (medical),Pharmacology
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